Thermostressine Peptide Powder

A comfort peptide for skin under daily stress

Heat, cold, wind and long days leave skin looking tired and tight. Thermostressine is a peptide used in leave-ons aimed at a more relaxed, comfortable-looking skin feel under that kind of stress. This page is the powder. The US catalog INCI is Acetyl Tetrapeptide-22 and the CAS is 1295648-76-8. Older solution grades of this active listed glycerin and water as carriers, but this listing is the dry peptide. Appearance is confirmed on the CoA for each lot.

How it compares

Delisens is a different comfort peptide with its own listing, and Calmosensine is a soothing-story peptide solution with a different INCI. There is no Thermostressine solution on our solution list, so the powder is the only form we carry. Other dry peptides are in our peptide powders.

Working with the powder

Dissolving

Weigh the powder on a calibrated balance, dissolve it completely in a small portion of the formula water before it meets the rest of the batch, and add that premix in cool-down, below 40 °C. Check that the premix is fully clear before you add it.

Compatibility

Keep it away from strong oxidizers and high-ionic-strength systems, such as products very rich in salts. A mild, water-rich base is the safest home.

Level

Take the use level from the supplier documentation for your lot.

Product types that suit it

Comfort serums, barrier creams, after-sun gels, winter face creams and sensitive-skin moisturizers.

Pairing ideas

D-Panthenol, allantoin, ceramides, sodium hyaluronate and oat-based ingredients. Add each active separately and check clarity, odor and viscosity after each addition instead of premixing several actives in one beaker.

Example architecture

The level comes from the CoA, so no gram recipe is shown here.

Claims

Describe skin that looks calmer, feels more comfortable and looks less stressed. Keep claims cosmetic and tied to appearance. Any before-and-after statement needs a test on the finished product, not on the raw material.

Testing the finished product

Run a stability check on the finished product at room temperature, at 40 °C and in a fridge for several weeks, and watch color, odor, clarity, viscosity and pH. Check the product in its final pack too, since pumps, droppers and jars expose it to air differently. A preservative challenge test on the final product is the standard step before launch.

Lot handling and storage

Record appearance and pH on arrival, compare them with the CoA, and keep the CoA with your batch records so each finished batch can be traced to its lot. Keep the powder tightly closed and dry, since peptides pick up moisture from the air, and respect the shelf life on the CoA.

Ordering

It is sold as a raw material for cosmetic formulation, not as a finished consumer product. Start with a small pack for bench trials and scale once your stability checks pass. It ships from Florida, usually within 1 to 2 business days, in the pack sizes shown above, and US shipping is free on orders of $50 or more.