Calmosensine

Calmosensine, a comfort peptide in solution

Calmosensine is a ready liquid built around Acetyl Dipeptide-1 Cetyl Ester, a short dipeptide that has been acetylated and given a cetyl ester tail so it sits comfortably with skin lipids. The full INCI reads Butylene Glycol, Aqua, Laureth-3, Hydroxyethylcellulose, Acetyl Dipeptide-1 Cetyl Ester, and the peptide carries CAS 196604-48-5. The liquid is yellow and opaque, mixes into water-based systems and ships from a 0.33 oz (10 mL) trial size, which is enough to run several bench batches before you scale.

Where the comfort story fits

Brands reach for this peptide when a product has to feel gentle on skin that reacts to cold, wind, shaving or rubbing. Finished creams and gel serums that contain it are described as soft, calm and balanced, without a sticky afterfeel. The supplier keeps the dose simple: about 3% in age care, 2 to 3% in sun and after-sun products and a lower 1 to 2% in children's cosmetics, where a mild, lightly scented or unscented base is the better partner.

Textures that suit an opaque liquid

Because the solution is not clear, it looks best in creams, lotions and milky gels rather than water-white toners. Comfort creams for sensitive-feeling skin, after-shave balms and after-sun lotions are the most natural homes.

Adding it to the batch

Stir Calmosensine into the water phase of a gel, or into an emulsion during cool-down below 40 °C, and avoid long periods of heat. Keep the finished pH in a skin-friendly range. For moisture, pair it with hyaluronic acid liquid, and for a botanical soothing note add bisabolol. If you want the same molecule as a dry material, the Idealift powder carries Acetyl Dipeptide-1 Cetyl Ester without the carrier. More pre-dissolved peptides sit in our peptide solutions section.