Acetyl Tetrapeptide-3 Powder

What Acetyl Tetrapeptide-3 Powder is

Acetyl Tetrapeptide-3 is a short synthetic peptide built from four amino acids, lysine, glycine, histidine and lysine, with an acetyl group on one end and an amide on the other. Its sequence is written Ac-Lys-Gly-His-Lys-NH2, its molecular formula is C22H39N9O5 and its CAS number is 827306-88-7. It is the peptide part of several well-known hair care complexes, including the liquid blend we sell as Capixyl Solution, where it is combined with a red clover extract.

This listing is the neat peptide as a white powder. Buying the peptide on its own gives you control over the dose and the vehicle, which a ready-made complex cannot do. It belongs with our other dry peptides in Peptide Powders.

Key properties

The material is a white solid powder. As an acetylated and amidated tetrapeptide it is a small, water-soluble molecule, which makes it practical in water-based serums and tonics. Purity is reported per lot by HPLC on the certificate of analysis, and that document is the reference for the batch you receive.

In cosmetic literature Acetyl Tetrapeptide-3 is discussed as a signal peptide for the scalp and the base of the hair. For product copy, keep claims to the look and feel of hair and scalp, and leave out any promise to stop thinning-looking hair or regrow hair, which would be a products claim.

Applications

Scalp serums and tonics

The most common home for this peptide is a leave-on scalp product, a light water or water and glycol tonic, or a thin serum applied directly to the scalp. Leave-on formats give the peptide contact time that a rinse-off shampoo does not.

Lash and brow serums

Gel serums for lashes and brows are another typical format. These are small, high-value products where a peptide powder is easy to dose precisely.

Conditioners and leave-ins

Leave-in conditioners and hair lotions can also carry the peptide, often alongside other actives. Biotinoyl Tripeptide-1, available as Biotinoyl Tripeptide-1 Powder, is a frequent partner in hair care concepts.

How to use

Dissolve the powder in a small portion of the water phase first and add it during cool-down, below about 40 degrees Celsius. Peptides are used at very low levels, so weigh on a balance that reads to 0.001 g, or prepare a stock solution in water and add that instead. The supplier sheet does not give a single recommended dose for the neat peptide, so confirm the working range with the lot documents and run a pilot batch.

Compatibility and processing notes

Keep the finished product in a mild pH range, and avoid strong oxidizers and high-heat steps after the peptide is added. Most common gelling agents and nonionic solubilizers are compatible. Check that your preservative system works at the final pH, since peptide serums are usually water-rich.

Appearance and specifications

The INCI name is Acetyl Tetrapeptide-3 and the CAS is 827306-88-7. The form is a white powder. The molecular formula is C22H39N9O5 and the molecular weight is about 509.6 g/mol.

Example formula: Peptide scalp tonic, 100 g

Weigh 88 g of distilled water and add 5 g of propanediol and 3 g of glycerin. Dissolve 0.3 g of hydroxyethylcellulose with stirring until clear. In a separate small beaker dissolve 0.05 g of Acetyl Tetrapeptide-3 Powder in 2 g of water, then add it to the main batch. Add 1 g of a broad-spectrum preservative suitable for leave-on products, adjust pH to the preservative's working range and top up to 100 g with water. This is a starting formula for development and needs stability and preservative testing before release.

Storage

Keep the sealed container in a refrigerator or a cool, dry place, away from light and moisture. Let the jar reach room temperature before opening so condensation does not form on the powder.