Palmitoyl Tripeptide-8 Solution

A calming peptide in a three-ingredient base

Palmitoyl Tripeptide-8 is a lipopeptide designed for the comfort brief: products for skin that flushes, stings or feels tight. This liquid keeps the label short, with just the peptide, water and glycerin, which suits clean-label and fragrance-free lines that want an active without a long carrier list. It is supplied to product developers as a raw material.

Composition and active content

The INCI is Palmitoyl Tripeptide-8, Aqua, Glycerin. Ready solutions of this peptide are colorless and typically carry the active at around 190 to 500 ppm; the exact content of your lot is printed on its certificate of analysis, which should drive your dosing.

Use level and dosing math

Published supplier data for ready Palmitoyl Tripeptide-8 liquids range from about 1 to 2.5% for concentrated grades to 2 to 5% for diluted ones, landing near 0.001 to 0.0025% pure peptide in the finished product. Convert with the peptide content on your CoA and start low in daily creams.

Formulating guidance

Phase, heat and pH

Add it to the water phase during cool-down, ideally as a final aqueous addition below 40 °C, and avoid holding the batch above 45 °C afterward. Supplier guidance places stability between roughly pH 4 and 7, with best results in the mildly acidic range most skin-care bases already sit in.

Clarity and compatibility

The palmitoyl chain makes the peptide partly lipophilic, so a faint haze in very clear gels is possible; a little butylene glycol or a mild solubilizer helps. Avoid strong oxidizers, strong acids, repeated freeze-thaw and clear packaging in direct light.

Where it earns its place

Brands use it in redness-prone and sensitive-skin creams, after-sun gels, post-shave balms, post-wax and leave-on cosmetic serum comfort products, and in retinoid or acid routines to support tolerance. Word claims around look and feel, such as less visible redness and a more comfortable feel, and test the finished product. It sits in our peptide solutions section.

Formula partners

It works well with Hyaluronic acid liquid 1%, panthenol, allantoin, centella and niacinamide. For a polysaccharide comfort layer, pair it with FucoLife GR; for a line-smoothing night cream add Palmitoyl Tripeptide-38 Solution.

Bottle sizes and cold storage

Sold in 1, 2, 4, 8 and 16 oz bottles from Florida with a CoA. Refrigerate, keep away from light and reseal promptly.