IO Expression-Line Peptide Liquid (Acetyl Hexapeptide-8)

This ingredient at a glance

IO Expression-Line Peptide Liquid (Acetyl Hexapeptide-8) is a liquid grade of Acetyl Hexapeptide-8 (CAS 616204-22-9) built for the oil side of a formula. The producer places the hexapeptide inside an inverse micelle carrier, which lets a peptide that normally lives in water dissolve in oils, esters and alkanes. Our record also notes that this grade does not mix with water or with silicones, so plan the vehicle around an oil or an ester rather than a gel. Pack sizes on this page are in fluid ounces.

Why an oil-soluble hexapeptide matters

Classic Acetyl Hexapeptide-8 is sold as a water solution, which leaves anhydrous products without an easy way to carry it. This grade closes that gap. Brands can now put the same well-known expression-line peptide into facial oils, clear oil serums, lip and eye sticks and balms without building an emulsion just to host it. The marketing message stays familiar: a face that looks more relaxed and smoother where expression lines form, delivered in a texture that shoppers already associate with nightly care.

Where it fits in a product range

Anhydrous serums and facial oils

A clear oil serum is the most natural home. Blend the peptide into a light ester or squalane base with a stable carrier oil, and the product stays transparent. Pair it with Bakuchiol for a retinol-free night oil story, or keep the formula short and let the peptide carry the claim.

Sticks and balms

Eye sticks, lip contour sticks and solid balms are another strong fit. Add the peptide to the melted oil and wax blend after it has cooled toward the pour temperature, stir well and pour. This route suits brands that want a portable expression-line product without water or preservatives in the base.

Oil phase of emulsions

In creams the peptide belongs in the oil phase rather than in the water. Add it to the cooled oil blend or into the finished emulsion below 40 °C, since long heating is not needed for a liquid that is already dissolved.

How to work with it

Shake or stir the container before weighing. Weigh into the oil phase and mix until the batch is uniform. Avoid adding it to water-only systems, where it will not dissolve, and keep it away from silicone-only bases. The card does not give an use percentage, so take the level from the supplier CoA for your lot. Keep strong acids, strong bases and oxidizers out of the same product.

Comparing it with other this ingredient grades

The classic this ingredient solution is a water-phase liquid for gels, toners and light emulsions. YOUth covers the opposite side of the formula: oils, esters and sticks. Some brands keep both on the shelf, using the water solution in a day gel and YOUth in a night oil, which lets one INCI name run through a whole routine. Other liquid peptides are gathered in our peptide solutions section.

Characteristics

Form: oil-soluble liquid. INCI of the active: Acetyl Hexapeptide-8, with the full carrier INCI confirmed on the supplier CoA. CAS: 616204-22-9. Solubility: oils, esters and alkanes; not water or silicones. Addition point: oil phase, below 40 °C in emulsions. Supply: fluid ounce packs.

Original recipe: peptide night oil, 100 g

Caprylic/capric triglyceride 45.00 g, squalane 30.00 g, jojoba oil 18.00 g, IO Expression-Line Peptide Liquid (Acetyl Hexapeptide-8) 5.00 g, tocopherol 1.00 g, bisabolol 0.50 g, sea buckthorn oil 0.50 g. Combine the oils at room temperature, add the peptide and tocopherol, and stir until the blend is clear and uniform. Fill into amber dropper bottles.

Storage

Keep the container tightly closed in a cool place away from light. Stir before use after long storage. Ships from Florida in the ounce sizes listed above.