SYN-COLL

SYN-COLL in brief

SYN-COLL is a cosmetic solution of Palmitoyl Tripeptide-5, a palmitoylated three-amino-acid peptide used in firming and wrinkle-depth leave-on products. The CAS is Mixture for the solution, with Palmitoyl Tripeptide-5 listed as 623172-55-4. Commercial grades often include glycerin in the vehicle; confirm the full INCI on the CoA.

What sets it apart

Palmitoyl Tripeptide-5 is a short lipopeptide modeled on a sequence associated with collagen-related signaling in trade literature. It gives brands a well-known firming peptide that is distinct from the Matrixyl family, so a serum can carry two different firming peptides with different stories.

Formulating with SYN-COLL

Process

Add the solution during cool-down, below 40 °C, and mix until uniform. The palmitoyl chain makes the peptide partly lipophilic, so a slight haze in clear gels is normal; a small amount of glycol or solubilizer often helps.

Bases

Firming serums, day and night creams, and eye creams are typical. In emulsions, add after cooling. Record pH and viscosity before and after addition. This card does not state a use percentage; follow the supplier documentation.

Where SYN-COLL sits in the catalog

The SYN-TC Powder blend also contains Palmitoyl Tripeptide-5 together with other actives; it is a separate product. Progeline (Trifluoroacetyl Tripeptide-2) is another firming tripeptide but a different INCI.

Pairing ideas

Pair SYN-COLL with Matrixyl 3000 for a two-family firming serum, or with an expression-line peptide such as Argireline for a broad age-care product. Add each peptide separately in cool-down.

Example: two-peptide firming serum architecture

Water, glycerin, a light gel former, SYN-COLL, a matrikine, hyaluronic acid and a validated preservative. Exact levels come from the supplier documentation. A slightly silky texture from a small amount of a light emollient improves the feel.

Claims

Keep claims cosmetic: firmer-looking skin, the look of reduced wrinkle depth, smoother texture. Avoid claiming collagen production in the skin unless supplier cosmetic test data supports it.

Stability and storage

Run stability at room temperature and 40 °C in the final packaging. Store tightly closed, cool and away from light.

Working with palmitoyl peptides in production

In production, add SYN-COLL after the batch has cooled and after any homogenizer step. If you use a solubilizer for clarity, premix it with the peptide in a small amount of batch water before adding it to the main tank. Rinse the weighing vessel with batch water so the full dose goes in.

Lot documentation

Record appearance and pH on arrival and compare them with the CoA. Keep the CoA with your batch records, and note the vehicle on the CoA, since commercial grades can differ in glycerin content.

Ordering

It ships from Florida, usually within 1 to 2 business days, in the pack sizes shown above, and US shipping is free on orders of $50 or more. Compare all peptide solutions.