Pentapeptide-18 Solution, IO

Pentapeptide-18 Solution is the trade name for Pentapeptide-18. The same INCI is also sold here as Pentapeptide-18.

The pentapeptide that is usually bought as a partner

Pentapeptide-18 Solution is rarely the only peptide in a product. Formulators tend to buy it to sit next to an Acetyl Hexapeptide-8 solution, building a two-peptide expression-line serum rather than relying on one sequence. Its INCI is Pentapeptide-18 and the published CAS for the peptide is 64963-01-5. This listing is a ready solution; commercial grades often list water and glycerin as the vehicle, and the exact INCI for each lot is confirmed on the CoA.

Where it sits among the expression-line peptides

Three names come up again and again in this category. Acetyl Hexapeptide-8 Solution is Acetyl Hexapeptide-8. Acetyl Octapeptide-3 Solution is Acetyl Octapeptide-3, a longer sequence in the same story. Pentapeptide-18 Solution is Pentapeptide-18, a different sequence that is marketed as working alongside them. None of them is a rename of another, so label each one by its own INCI. You can see them side by side in our peptide solutions. A dry grade, Pentapeptide-18 powder, is also listed as a separate SKU.

Working with the solution

Phase and temperature

Add it in cool-down, below 40 °C, with gentle mixing, and avoid long holds at high temperature. It blends straight into the water phase of serums, gels and finished emulsions. In emulsions, add it after the emulsion has formed and cooled.

Level

This card does not state a use percentage, so follow the CoA and the supplier documentation for the level. If you stack it with Acetyl Hexapeptide-8, set each peptide at its own documented level instead of splitting one level between them.

Product types that suit it

Forehead and crow's-feet serums, eye gels, eye creams and smoothing primers are the classic homes. Light water-gels let the peptide work without heavy texture, and silicone-feel primers give a quick smoothing look at the same time.

Pairing ideas

Acetyl Hexapeptide-8 is the obvious partner. Hyaluronic acid and glycerin add a plumper, hydrated look, and caffeine is a common companion in eye products. Add each active separately and check clarity, odor and viscosity after each addition instead of premixing several actives in one beaker.

Example eye gel architecture

Water, glycerin, a light carbomer or polymer gel, Pentapeptide-18 Solution and an Acetyl Hexapeptide-8 solution at their supplier levels, panthenol, a chelator and a broad-spectrum preservative. The levels come from the CoA, so no gram recipe is given here. A pump or a cooling metal applicator suits the eye area.

Claims

Describe the look of expression lines appearing softer with regular use. Keep claims cosmetic and tied to appearance. Any before-and-after statement needs a test on the finished product, not on the raw material.

Testing the finished product

Run a stability check on the finished product at room temperature, at 40 °C and in a fridge for several weeks, and watch color, odor, clarity, viscosity and pH. Check the product in its final pack too, since pumps, droppers and jars expose it to air differently. A preservative challenge test on the final product is the standard step before launch.

Lot handling and storage

Record appearance and pH on arrival, compare them with the CoA, and keep the CoA with your batch records so each finished batch can be traced to its lot. Store tightly closed, cool and away from light, and respect the shelf life on the CoA.

Ordering

It is sold as a raw material for cosmetic formulation, not as a finished consumer product. Start with a small pack for bench trials and scale once your stability checks pass. It ships from Florida, usually within 1 to 2 business days, in the pack sizes shown above, and US shipping is free on orders of $50 or more.