Pentapeptide-18 Powder

What Pentapeptide-18 is

Pentapeptide-18 is a synthetic peptide of five amino acids, CAS 64963-01-5, designed after enkephalins, small natural peptides. In cosmetics it is one of the classic expression-line peptides and is best known as the active in pentapeptide-18 solutions. This page sells the pure powder by the gram, which suits brands that want to choose their own concentration and vehicle. If you prefer a liquid, see pentapeptide-18 Solution.

How it is positioned

Supplier literature describes Pentapeptide-18 as working on a different step of the same cosmetic theme as Acetyl Hexapeptide-8, which is why the two are so often sold together. The consumer message is about a more relaxed, smoother look in areas of repeated movement such as the forehead, between the brows and around the eyes. The powder forms a clear solution in water, so it suits transparent serums.

Applications

The record lists facial serums, creams, eye contour care, gels and concentrates, professional cosmetology and salon care. Typical finished products are expression-line serums, eye creams, forehead fluids, ampoules and roll-ons. The classic pairing is with Acetyl Hexapeptide-8 Powder; a third peptide like Dipeptide Diaminobutyroyl Benzylamide Diacetate Powder completes a popular trio. Compare more dry peptides in our peptide powders section.

How to dissolve and add it

Weigh the powder with a precise balance. Dissolve it completely in a small amount of distilled water until the mixture is clear. Add the dissolved peptide to the batch during cool-down, below 40 °C, and mix gently. Avoid prolonged heat. Take the use level from the supplier documentation for your lot.

A two-peptide strategy

Combining Pentapeptide-18 with Acetyl Hexapeptide-8 is a well-established way to build an expression-line product. Dissolve each peptide separately, add them one after the other and stir between additions. Keep each within its own CoA range rather than pushing both to the maximum. Choose a light gel or fluid emulsion for daytime and a richer cream for night, and package in airless pumps to keep the product clean.

Compatibility

Pentapeptide-18 is compatible with water, glycerin, glycols, hyaluronic acid, panthenol, niacinamide and other peptides. It works in gels, serums and oil-in-water emulsions. Avoid strong acids, strong bases, oxidizers and long heating. Copper peptides are best placed in a separate product. If you combine the peptide with caffeine for an eye product, dissolve the caffeine in warm water first and let the solution cool before adding the peptide, so the peptide never meets heat.

Characteristics

Form: powder. INCI: Pentapeptide-18. CAS: 64963-01-5. Solubility: water. Addition point: cool-down after full dissolution.

Communicating results honestly

Peptide products for expression lines sell best with realistic expectations. Describe the look you aim for, such as a smoother, more rested appearance with regular use over several weeks, and avoid any comparison with injections. Before-and-after imagery should be unretouched and taken in identical light. Simple, consistent messages build trust with shoppers who already know the ingredient name.

Original recipe: forehead smoothing fluid, 100 g

Peptide premix: Pentapeptide-18 Powder 0.03 g and Acetyl Hexapeptide-8 Powder 0.05 g, each dissolved in distilled water 4.00 g. Phase A: distilled water 83.42 g, glycerin 3.00 g, propanediol 3.00 g. Phase B: caprylic/capric triglyceride 3.00 g, sodium acrylates copolymer and lecithin 1.50 g; stir into An until a fluid forms. Phase C below 40 °C: the peptide premixes, panthenol 1.00 g, sodium hyaluronate 0.10 g predissolved, preservative 0.90 g. Mix gently and adjust pH to about 6.0.

Storage

Keep the powder sealed, cool and dry, away from light and humidity. Allow it to reach room temperature before opening. Ships from Florida in gram packs.