Palmitoyl Pentapeptide-4 Powder, IO

This ingredient explained

Palmitoyl Pentapeptide-4 Powder is the dry powder of Palmitoyl Pentapeptide-4, CAS 214047-00-4, also written Pal-KTTKS. The KTTKS part is a five-amino-acid sequence, lysine, threonine, threonine, lysine and serine, found in a fragment of type I procollagen. Attaching palmitic acid improves the peptide's affinity for the skin surface. Introduced in the early 2000s, it was one of the first signal peptides to reach mass-market skin care and remains a reference point for the category. This page sells it as a powder by the gram.

Properties

Palmitoyl Pentapeptide-4 is presented as a matrix peptide: brands use it in products aimed at smoother, firmer and more resilient-looking skin, especially for fine lines around the eyes and on the forehead.The pure powder lets you set the concentration yourself and keep the label short.

Applications

The supplier record lists anti-age serums, active gels, leave-on makeup removal products, creams and gels for the eye area, masks, anti-age creams and lotions and lifting products. Many brands pair it with expression-line peptides such as Acetyl Hexapeptide-8 Powder or with the newer Palmitoyl Tripeptide-38 Powder for a layered peptide story. See more dry peptides in our peptide powders section.

How to dissolve and add it

Weigh the powder on a precise balance. Dissolve it fully in water or the solvent system recommended on the CoA; palmitoylated peptides sometimes benefit from a glycol co-solvent or a small amount of solubilizer. Add the dissolved peptide during cool-down, below 40 °C, with gentle mixing. Avoid prolonged heat. The card does not state an use percentage; follow the CoA.

Writing the product story

Use that recognition, but keep claims about the look and feel of skin. Pair the peptide with a humectant for immediate comfort and a texture suited to the moment of use, a gel for mornings and a cream for evenings. A clear INCI line, Palmitoyl Pentapeptide-4, reassures ingredient-savvy buyers.

Compatibility

Palmitoyl Pentapeptide-4 is compatible with hyaluronic acid, glycerin, panthenol, niacinamide, allantoin, plant extracts and other peptides. It suits gels, serums and oil-in-water emulsions. Avoid strong acids, strong bases, oxidizers and long heating, and keep copper peptides in a separate product. In leave-on makeup removal products, add the peptide after the mild surfactant or oil phase is complete, and keep the product gentle enough for the eye area.

Characteristics

Form: powder, confirm the exact appearance on the CoA. INCI: Palmitoyl Pentapeptide-4. CAS: 214047-00-4. Solubility: water-soluble with full dissolution, follow CoA solvent advice. Addition point: cool-down.

Original recipe: peptide eye gel, 100 g

Peptide premix: Palmitoyl Pentapeptide-4 Powder 0.01 g stirred into propanediol 1.00 g, then diluted with distilled water 2.00 g until clear. Phase A: distilled water 86.49 g, glycerin 3.00 g, hydroxyethylcellulose 1.00 g; hydrate until clear. Phase B below 40 °C: the peptide premix, caffeine 0.80 g in warm water, panthenol 1.00 g, sodium hyaluronate 0.10 g predissolved, cucumber extract 3.70 g. Phase C: eye-safe preservative 0.90 g. Mix gently and adjust pH to about 6.0.

Record the lot number in your batch log so every production run can be traced back to its certificate of analysis. Retain a small sample of each lot for at least the shelf life of the finished product, since it makes later quality questions much easier to answer.

Storage

Keep the powder sealed, cool and dry, away from light. Let the container reach room temperature before opening. Ships from Florida in gram packs.