Palmitoyl Tripeptide-38 Powder, IO

This ingredient in focus

Palmitoyl Tripeptide-38 Powder is Palmitoyl Tripeptide-38, CAS 1447824-23-8.On this page it is sold as the dry white powder by the gram. That gives you the pure active, without a carrier, and full control over concentration. The supplier CoA notes any co-solvent advice, which is worth reading before your first batch.

What it does in a product

The palmitoyl chain improves affinity for the skin surface, while the peptide sequence belongs to the family of matrix-themed signal peptides. Brands use it to tell a firming and filling story: skin that looks plumper, smoother and more resilient, especially on the forehead and around the eyes. It is one of the newer members of this ingredient family and is often chosen as a step up from Palmitoyl Pentapeptide-4 Powder.

Applications

The record names firming and appearance support serums. In practice, this ingredient is found in eye contour creams, forehead serums, night creams, neck and decolletage products and premium multi-peptide serums. It pairs with expression-line peptides such as Hexapeptide-9 Powder and with humectants for an immediate plumping feel. Browse more dry actives in our peptide powders section.

How to dissolve and add it

Weigh accurately and dissolve the powder fully in distilled water. If the CoA notes a co-solvent, such as a glycol, premix the powder in it first. Add the dissolved peptide to the batch during cool-down, below 40 °C, with gentle mixing. Do not reheat. The card does not state an use percentage; follow the CoA for your lot and keep the finished pH in a mild range.

Building a multi-peptide serum

A popular approach is to combine one matrix-themed peptide, one expression-line peptide and one humectant in a light gel. This ingredient fills the first role. Add each peptide separately into the cooled base and stir between additions. Clear gels show haze immediately, so they are useful for checking compatibility before you move to a cream. Keep notes of each lot number for traceability.

Compatibility

Palmitoyl Tripeptide-38 is compatible with hyaluronic acid, glycerin, panthenol, niacinamide, allantoin and other peptides. It suits gels, serums and oil-in-water emulsions. Avoid strong acids, strong bases, oxidizers and long heating. If you add a copper peptide, place it in a separate product, as copper can interact with other peptides. Keep strong fragrances away from eye products built with this peptide, and choose a preservative system validated for the delicate eye area.

Characteristics

Form: white powder. INCI: Palmitoyl Tripeptide-38. CAS: 1447824-23-8. Solubility: water-soluble, confirm any co-solvent note on the CoA. Addition point: cool-down after full dissolution.

Original recipe: firming eye cream, 100 g

Phase A: distilled water 71.40 g, glycerin 4.00 g, xanthan gum 0.20 g. Phase B: cetearyl alcohol and cetearyl glucoside 4.00 g, squalane 6.00 g, shea butter 2.00 g, caprylic/capric triglyceride 5.00 g. Heat An and B to 75 °C, emulsify and cool. Phase C below 40 °C: Palmitoyl Tripeptide-38 Powder 0.02 g dissolved in distilled water 3.98 g, caffeine 0.50 g in warm water, panthenol 1.00 g, tocopherol 0.40 g, eye-safe preservative 1.00 g, water 0.50 g. Mix until smooth and adjust pH to about 6.0.

Record the lot number in your batch log so every production run can be traced back to its certificate of analysis. Retain a small sample of each lot for at least the shelf life of the finished product, since it makes later quality questions much easier to answer.

Storage

Keep the powder sealed in a cool, dry place away from light and humidity. Close it right after weighing. Ships from Florida in gram packs.