Nanoliposomes complex with tripeptide 29

A liposomal collagen-fragment complex

This nanoliposome complex carries Tripeptide-29, a collagen-fragment-type tripeptide, together with supporting actives inside phospholipid vesicles. The catalog INCI is Phospholipids, Tripeptide-29, Hyaluronic Acid, Yeast Extract, Chondroitin Sulfate, Tocopherol. CAS is shown as Mixture, with Tripeptide-29 listed as 2239-67-0. The result is a multi-active liquid for firming-positioned leave-on products.

What each component brings

Phospholipids form the liposome shell and give a soft, skin-friendly feel. Tripeptide-29 is the headline peptide. Hyaluronic acid and chondroitin sulfate are humectant polysaccharides that support hydration and a plump-looking surface. Yeast extract is a conditioning ingredient, and tocopherol (vitamin E) protects the lipids from oxidation. Together they make a complex that reads well on a label and covers several claims at once.

Working with liposomes

Gentle processing

Liposomes are delicate. Add the complex during cool-down, below 40 °C, and mix at low shear. Avoid homogenizers after addition, strong surfactants in the same phase and high levels of alcohol, all of which can break the vesicles.

Bases

Gel-creams, serums thickened with skin-friendly polymers, and light emulsions work well. Record pH, appearance and viscosity before and after addition. Take the use level from the supplier documentation for your lot.

How it differs from other firming actives

This complex is not Palmitoyl Tripeptide-5 and not Palmitoyl Tripeptide-1 + Palmitoyl Tetrapeptide-7 Liquid. The related AC Collagen Prepeptide PF is a plain Tripeptide-29 liquid without the liposome and support actives. Choose the complex when you want a ready multi-active system, and the plain peptide when you want to set each ingredient yourself.

Claims

Keep claims cosmetic: firmer-looking, plumper-looking, well-hydrated skin. Liposomal delivery is a formulation feature; avoid claims that the product penetrates to a particular skin layer unless supplier data supports it.

Stability and storage

Run stability at room temperature and 40 °C in the final packaging, checking appearance for separation or creaming. Store the complex cool and away from light; do not freeze unless the supplier documentation allows it.

Example: firming gel-cream architecture

A firming gel-cream could combine water, glycerin, a skin-friendly polymer gel, a small oil phase emulsified with a mild emulsifier, and the Tripeptide-29 nanoliposome complex added after cooling, with a preservative validated for the whole formula. Exact levels come from the supplier documentation. Because the complex already carries hyaluronic acid and chondroitin sulfate, you may need less additional humectant than in a standard formula.

Avoiding liposome damage in production

In production, add the complex at the very end, after any homogenizer step, and use a paddle or anchor mixer at low speed. Keep surfactant-rich ingredients such as solubilized fragrances in a separate premix and add them before the liposomes.

Ordering

It ships from Florida, usually within 1 to 2 business days, in the pack sizes shown above, and US shipping is free on orders of $50 or more. Compare all peptide solutions.