Biotinoyl Tripeptide-1 Solution (Biotinyl-GHK)

Biotinoyl Tripeptide-1 is also written biotinyl-GHK: biotin linked to the GHK tripeptide.

Biotin joined to GHK

Biotinoyl Tripeptide-1 links biotin, the familiar B-vitamin, to the GHK tripeptide. The result is a cosmetic peptide that has become a standard in lash serums, brow gels and scalp products that promise fuller, stronger-looking hair. This page is the INCI-named solution, CAS 299157-54-3. The full vehicle INCI is confirmed on the CoA for each lot.

How it differs from other hair peptides

Biotinoyl Tripeptide-1 is a single defined peptide. It is not the same as a branded multi-ingredient complex. Acetyl Tetrapeptide-3 + Red Clover Extract Hair Complex Peptide, for example, combines a different peptide with a plant extract. For lash products, buyers often pair this peptide with Eye Lash Hexa Peptide, and both sit in our peptide solutions.

Formulating with the solution

Phase and temperature

Add it in cool-down, below 40 °C, with gentle mixing, and avoid long holds at high temperature. It blends into water-based gels, tonics and light emulsions.

Level

Take the use level from the supplier documentation for your lot.

Base design

Lash serums need a thin, quick-drying base that will not run into the eye: water, a little glycerin, a thin polymer and a preservative validated for eye products. Scalp tonics can carry more water and a little alcohol if the supplier documentation allows it; check clarity after the addition.

Product ideas

Lash and brow serums, tinted brow gels, leave-in scalp tonics, overnight scalp serums, conditioning hair sprays and thickening-look shampoos. In rinse-off products, contact time is short, so leave-ons are the stronger home for the peptide story.

Pairing ideas

Myristoyl Pentapeptide-17, Myristoyl Hexapeptide-16, panthenol and plant extracts are common companions in multi-active lash serums. In scalp products, niacinamide, caffeine and panthenol fit well. Add each active separately and check clarity after each one.

Example: brow and lash serum architecture

Water, glycerin, a thin gel former, Biotinoyl Tripeptide-1, a second lash peptide and panthenol, with an eye-safe preservative. Exact levels come from the supplier documentation, so no gram recipe is given. A fine liner brush in a slim tube allows precise application.

Claims

Keep claims cosmetic: lashes and brows look longer, fuller and healthier; hair looks thicker. Avoid wording that implies a physiological effect on hair. Eye-area claims need tests on the finished product.

Lot handling and storage

Record appearance and pH on arrival, compare them with the CoA, and keep the CoA with your batch records so each finished batch can be traced to its lot. Store tightly closed, cool and away from light.

Stability checks before scale-up

Run a small pilot batch first. Keep samples at room temperature, in a warm cabinet and in the fridge, and check color, odor, clarity, viscosity and pH at set intervals over several weeks. Test the product in the final pack as well as in glass, because pumps, droppers and tubes can change how a peptide product ages. Write every observation into the batch record next to the lot number of the raw material.

Ordering

The solution is a raw material for cosmetic formulation, sold from a 0.33 oz (10 mL) sample up to bulk sizes. It ships from Florida, usually within 1 to 2 business days, in the pack sizes shown above, and US shipping is free on orders of $50 or more.